Pharmaceutical Laboratory Instruments in Pakistan

Analytical instruments, pharmaceutical quality-control systems and laboratory infrastructure for GMP-oriented QC, QA and R&D laboratories.

From assay and water determination to raw-material identification, ionic impurities, trace metals, optical measurements and sample preparation, CWTC brings together Metrohm, BÜCHI, ELGA LabWater, ATAGO, IWAKI, JULABO and asecos instruments and equipment.

Pharmaceutical quality control laboratory

Pharmaceutical Analysis & Quality Control

Choose equipment around the actual pharmacopeial monograph, sample matrix, analytical method and data-integrity requirement—not simply by instrument type. The sections below follow the portfolio in the CWTC pharmaceutical brochure.

Potentiometric Titration

Pharmaceutical assays, non-aqueous acid/base titrations, redox, complexometric and precipitation methods. Choose a routine stand-alone system or a more configurable, automated platform for demanding QC workflows.

Metrohm Eco Titrator

Metrohm Eco Titrator

Compact touchscreen titrator for established routine QC methods, with straightforward operation, reporting and optional data transfer.

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Metrohm 916 Ti-Touch

916 Ti-Touch

Stand-alone touchscreen titration with configurable measuring and dosing modules; suited to sophisticated routine and regulated QC requirements.

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Metrohm Titrando with Touch Control

Titrando

Flexible software-controlled titration platform for advanced methods, dosing, automation and integration with laboratory workflows.

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Metrohm OMNIS Titrator

OMNIS Titrator

Modular PC/network-operated platform for potentiometric and other supported titration techniques, parallel workflows and sample automation.

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Acid–base & non-aqueous Redox Argentometric Complexometric Automation options

Karl Fischer Titration & Coulometry

Volumetric and coulometric water determination for pharmaceutical raw materials, APIs, excipients, intermediates and finished products. Oven techniques can help with samples that are insoluble or incompatible with direct reagent addition.

Metrohm Eco KF

Eco KF / Eco Coulometer

Compact routine water-determination systems with straightforward operation and options for oven-assisted workflows.

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Metrohm 915 KF Ti-Touch

915 KF Ti-Touch / Coulometer

Stand-alone touchscreen configurations for volumetric or coulometric water analysis, with possible sample automation and KF ovens.

View 915 KF →
Metrohm Titrando KF Coulometer

Titrando Karl Fischer

PC-controlled volumetric and coulometric KF workflows with advanced method control, documentation and accessory options.

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Metrohm OMNIS KF Titrator

OMNIS Karl Fischer

Modular software platform for compliant-laboratory KF workflows, integrated liquid handling and higher levels of automation.

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Application extension: Consider a KF oven / Thermoprep where direct titration is problematic, including selected solid excipients and formulations. Suitability and operating temperature must be validated for each matrix.
Metrohm IONIC Titrator

The IONIC Titrator

Metrohm's stand-alone platform brings PC-class data handling to the titrator with a 10-inch display, onboard storage, parallel titrations, up to four burets, potentiometric and volumetric KF capability and connected data options.

250,000 dosing steps Parallel titrations 21 CFR Part 11 support Cloud data options

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Ion Chromatography for Pharmaceutical Analysis

Ion chromatography extends beyond routine inorganic ions to pharmacopeial assays, API counterions, ionic impurities, pharmaceutical infusions and selected antibiotic-related methods. Metrohm's 930 Compact IC Flex and configurable 940 Professional IC Vario address different method and throughput requirements.

Metrohm 930 Compact IC Flex

930 Compact IC Flex

Compact IC for routine assays of inorganic anions, cations and other suitable ionic substances with the appropriate columns and detection.

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Metrohm 940 Professional IC Vario

940 Professional IC Vario

Configurable IC for advanced separations, challenging matrices, automation and flexible detectors; method-specific configurations may include conductivity and electrochemical detection.

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Selected Metrohm Pharmaceutical IC Application Notes

AN-S-398 · Phosphate injections

Phosphate in sodium and potassium phosphates compounded injections; USP-oriented IC method.

Read application note →
AN-CS-021 · Sodium in compounded injections

Sodium in sodium bicarbonate and sodium phosphates compounded injections by IC.

Read application note →
AN-C-111 · Cefepime hydrochloride

N-methylpyrrolidone impurity in cefepime hydrochloride by cation chromatography.

Read application note →
AN-N-051 · Infusion solution

Acetate, chloride, citrate and sulfate in an amino-acid/dipeptide infusion concentrate.

Read application note →
AN-S-373 · Effervescent tablets

Chloride in potassium bicarbonate and potassium chloride effervescent tablets.

Read application note →
AN-P-080 · Gentamicin

Gentamicin components using chromatographic separation and pulsed amperometric detection; special detector setup required.

Read application note →
Method compliance: A Metrohm application note demonstrates a defined workflow, not automatic compliance of every instrument configuration. Check the current USP monograph and method, selected column, detector, system suitability, data handling and laboratory validation.
Metrohm 884 Professional VA

884 VA (Voltammetric Analysis) — Iron Sucrose Injection

USP-oriented Fe(II) impurity determination. Metrohm Application Note AN-V-127 describes measuring the iron(II) limit in iron sucrose injection by differential-pulse polarography using the 884 Professional VA and viva software.

  • Distinguishes electrochemical responses of Fe(II) and Fe(III).
  • Supports documented Fe(II) content determination in an iron sucrose formulation.
  • Dedicated Multi-Mode Electrode pro configuration and method setup required.
This is Fe(II) limit testing, not a direct total-iron assay. Metrohm's application determines total iron separately using AAS for the calculation.
AN-V-127 · Fe(II) in iron sucrose injection → 884 Professional VA →
Further iron-speciation opportunity: Metrohm also documents Fe(II)/Fe(III) speciation in iron citrate capsules (AN-V-241). See application →

Raman Spectroscopy for Pharmaceutical Raw Material Identification

Handheld Raman instruments support rapid, non-destructive identification of incoming APIs, excipients and other suitable raw materials. MIRA P and NanoRam 1064 support identity testing at receiving, warehouse and laboratory locations; excitation wavelength and sample suitability determine the appropriate platform.

Metrohm MIRA P with accessories

MIRA P — 785 nm Raman

Portable pharmaceutical raw-material identification with suitable through-container sampling, PASS/FAIL libraries and accessories for incoming goods and QC.

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Metrohm NanoRam 1064

NanoRam 1064 — Handheld Raman

1064 nm excitation helps reduce fluorescence interference when identifying challenging pharmaceutical raw materials, including some colored excipients and complex formulations.

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100% incoming-material ID workflows Non-destructive analysis Warehouse & laboratory testing
Raman identity methods require suitable spectral libraries, sampling procedures and validation. Through-container testing and material discrimination depend on packaging, sample and method suitability.
Metrohm OMNIS NIR analyzer for pharmaceutical quantitative analysis

OMNIS NIR — Quantitative Pharmaceutical Analysis

Metrohm OMNIS NIR enables fast, non-destructive, reagent-free analysis of suitable pharmaceutical solids and liquids. With calibrated chemometric models, NIR can quantify selected material properties and components, rather than serving only as a raw-material identification technique.

  • Quantitative moisture determination in suitable excipients and powders.
  • Assay or concentration prediction for selected APIs and formulations.
  • Blend uniformity and process-related screening where validated.
  • Rapid routine QC after model development and reference-method calibration.
Explore OMNIS NIR Analyzer → AN-NIR-122 · Water in lactose →
Quantitative methods: NIR results depend on representative calibration samples, a suitable reference method, model validation and ongoing performance monitoring. It does not automatically replace compendial assays or Karl Fischer methods.

ELGA Pure & Ultrapure Laboratory Water

Reproducible laboratory water for standards, reagent preparation, chromatography, spectroscopy and analytical QC. Water-system grade, capacity and monitoring must be selected for the actual laboratory use; a purification system alone does not qualify a pharmaceutical water system.

ELGA PURELAB Quest

PURELAB Quest / Quest UV

Compact system designed to provide Type I, II and III laboratory water from one tap-fed configuration; Quest UV is available for low-organic-content applications.

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ELGA PURELAB Flex 3

PURELAB Flex 3

Type I ultrapure water with flexible dispensing and real-time TOC monitoring for demanding analytical laboratory use.

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ELGA PURELAB Chorus 1

PURELAB Chorus 1 Complete TOC

Higher-capacity tap-to-ultrapure configuration for laboratories with substantial daily demand, point-of-use quality monitoring and storage options.

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BÜCHI Sample Preparation & Pharmaceutical Testing

Controlled solvent evaporation, Kjeldahl nitrogen determination and melting/boiling point testing for analytical QC, sample preparation and formulation research.

BÜCHI Rotavapor

Rotavapor Systems

Gentle solvent removal, concentration, purification and recovery, with vacuum, chilling and control accessories as appropriate.

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BÜCHI Kjel Line

Kjel Line K-365

Steam distillation for applicable Kjeldahl/TKN and nitrogen-related testing, configurable reagent dosing and associated digestion/titration workflows.

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BÜCHI Melting Point M-565

Melting Point M-565

Automated melting and boiling point analysis with video documentation, a useful identity/purity-related physical measurement where prescribed.

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ATAGO Optical Measurements for Pharmaceutical QC

Optical methods support refractive index, Brix, concentration and optical rotation measurement for applicable ingredients, solutions and formulated products.

ATAGO RX Series

ATAGO RX Series

Precise digital refractive index and concentration measurement with temperature control; compatible data-handling and RefractoSoft options depend on model and software configuration.

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ATAGO SAC-i Polarimeter

ATAGO SAC-i Polarimeter

Automatic optical/specific rotation measurement for optically active pharmaceutical substances, with configurable temperature and data-reporting functions.

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General Equipment for Pharmaceutical Laboratories

Alongside analytical instruments, CWTC supplies measurement, volumetric glassware, temperature control and hazardous-material storage needed for a functioning pharmaceutical QC laboratory.

Metrohm laboratory pH meter

pH, Conductivity, DO & Ion Meters

Portable and bench systems for routine measurement, reporting and appropriate conductivity applications.

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IWAKI Class A glassware

IWAKI Class A Glassware

Batch-traceable volumetric flasks, pipettes, cylinders and burettes for standards, dilutions and titration solutions.

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JULABO laboratory temperature control

JULABO Temperature Control

Water baths and heating/refrigerated circulators for sample conditioning, controlled reactions and test temperatures.

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asecos safety cabinet

asecos Safety Cabinets

Type 90 flammable liquid storage plus model-dependent storage options for acids, alkalis and compressed gas cylinders.

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Qualification, Documentation & Data Integrity

Features such as audit trails, user permissions, controlled electronic records, IQ/OQ and LIMS connectivity depend on the exact instrument, software version, licenses and configuration—not every product offers every capability.

21 CFR Part 11-supporting configurations Audit trail / user management IQ/OQ services where applicable Application training Preventive maintenance
A laboratory's validated processes, SOPs, access controls and electronic-record procedures are required in addition to instrument functionality. Consult CWTC about the configuration and documentation suitable for your GMP workflow.

Pharmaceutical Laboratory FAQs

Which pharmaceutical QC applications does CWTC cover?
Potentiometric titration, Karl Fischer water determination, ion chromatography, Raman/NIR spectroscopy, Fe(II) impurity analysis by voltammetry, laboratory water, physical property measurements, sample preparation and supporting equipment.
Can CWTC support 21 CFR Part 11 requirements?
Selected Metrohm and ATAGO systems can be configured with features designed to support electronic-record controls. Suitability depends on the specific hardware, software and laboratory validation; purchasing a compliant-capable instrument does not by itself make a laboratory compliant.
Is the 884 Professional VA suitable for iron sucrose injection?
Metrohm Application Note AN-V-127 documents USP-oriented determination of Fe(II) in iron sucrose injection using differential-pulse polarography and the 884 Professional VA. Total iron is determined separately for the method calculation.
Which pharmaceutical applications can ion chromatography cover?
Examples include drug substance counterions, chloride and sulfate impurities, electrolytes in compounded injections, selected antibiotic-related substances and multi-ion infusion solutions. See the application notes above for matrix-specific demonstrations.
When should a lab use NanoRam 1064 rather than a 785 nm Raman unit?
1064 nm excitation can reduce fluorescence from some colored or complex raw materials. The appropriate Raman platform depends on sample chemistry, packaging, required identification method and validation results.
Is NIR a replacement for Karl Fischer?
No automatic substitution should be assumed. NIR can provide rapid model-based predictions after calibration and validation against an appropriate reference method such as Karl Fischer, where suitable.
Can CWTC help with laboratory equipment installation and qualification?
CWTC provides product selection, installation, operator and application training, preventive maintenance and technical service. Discuss IQ/OQ and other qualification documentation in the context of the chosen manufacturer's system.

Planning a Pharmaceutical QC or R&D Laboratory?

Share the sample matrix, relevant USP/Ph. Eur. method, expected throughput and documentation requirements. CWTC can recommend a suitable analytical system, supporting preparation equipment and local services.

Discuss Your Laboratory Requirement →